Effects of intranasal administration of multi-walled carbon nanotube (MWCNT) suspension on respiratory syncytial virus (RSV) infection in mice
نویسندگان
چکیده
To evaluate the effects of multi-walled carbon nanotubes (MWCNT) on a host immune system, we assayed them using murine model respiratory syncytial virus (RSV) infection. MWCNT suspended in solution were intranasally administered to mice days 1, 3, and 5 before RSV On day post-infection, levels representative inflammatory markers (interferon-γ, chemokines CCL3 CCL5) bronchoalveolar lavage fluid (BALF) significantly increased RSV-infected due exposure compared control. A histopathological analysis confirmed exacerbation pneumonia. However, significant changes not observed mock-infected this study. Some alveolar macrophages engulfing aggregates localized cells lung tissues, but RSV-positive immunohistopathologically stained with an anti-RSV antibody apart from those cells. Thus, intranasal treatment should affect pulmonary response against RSV, exacerbating infection mice.
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ژورنال
عنوان ژورنال: Fundamental Toxicological Sciences
سال: 2021
ISSN: ['2189-115X']
DOI: https://doi.org/10.2131/fts.8.215